PMCC ID Unit meeting 2025 Series
Do you have a ICH&Infections case to present? We’d love to hear from you!
We invite registrars/fellows or clinicians to present a clinical case in the area of infection in an immunecompromised host (haematology, transplant, immunodeficiency) to a large national and international audience to expand knowledge and/or to seek expert discussion.
Duration: 30 minutes (10–15-minute case presentation, followed by 10-minute brief literature review then 5-minute questions)
When: Thursdays 12.30pm (AEST time) – Microsoft teams
Topics: Diagnostic dilemnas, breakthrough infections, novel diagnostics, interesting radiology, management issues with intolerance, drug interactions or adverse effects.
Contact: To discuss or arrange a date please contact our ID fellow Nalian.Ibrahim@petermac.org or Michelle.Yong@petermac.org
A fascinating ICH&I case
A case of disseminated Strongyloidiasis infection in a young immunocompromised host
Recently we heard from NCIC Research Fellow Dr Lauren McShane on a patient with significant immunosuppression for pemphigus vulgaris who developed disseminated strongyloidiasis, despite negative pre-immunosuppression Strongyloides serology. They presented with pancolitis and respiratory failure, complicated by disseminated Klebsiella pneumoniae infection, ileus requiring subcutaneous ivermectin, and eosinophilic meningitis. They developed encephalopathy with features of ivermectin toxicity and was found to have an ABCB1 drug efflux pump mutation. Despite supportive care, their encephalopathy persisted six weeks post-ivermectin cessation. An intralipid infusion for ivermectin toxicity was trialled, with objective neurological improvement.