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People

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Dr Gabrielle Haeusler

Department of Infectious Diseases, Peter MacCallum Cancer Centre and Royal Childrens Hospital

Gabrielle is a peadiatric infectious diseases physician at the Royal Childrens Hospital with a special interest in kids with cancer. Gab performed her PhD in the NCIC evaluating a clinical decision rule for early oral antibiotic switch and discharge in patients who would traditionally remain in hospital for the duration of their antibiotic treatment.

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Dr Brendan McMullan

Sydney Children’s Hospital

Brendan is a paediatric infectious diseases physician, microbiologist and PhD student. His research interests include antimicrobial stewardship and resistance, and infections in immunocompromised children and young people, with particular interest in utilizing surveillance data in these populations to support implementation of effective strategies to optimize antimicrobial therapy.


Programs

Paediatric Low-risk febrile neutropenia program


Educational resources

Free online course On paediatric fever and neutropenia


Publications and Guidelines


Research

PICCNIC

The Predicting Infectious ComplicatioNs In Children with Cancer (PICCNIC) study.

Project Lead : Dr Gabrielle Haeusler

Fever and neutropenia (FN), is the most common complication of the treatment of childhood cancer and the leading cause of unplanned hospital admissions. Of those children diagnosed with FN a severe infection, such as bacteraemia or pneumonia, is documented in fewer than half of all episodes. A number of paediatric clinical decision rules exist identify children at low-risk for severe infection who may qualify for reduced intensity treatment. However, due to a paucity of validation and implementation studies many centres continue to admit all children with FN for intravenous antibiotics, irrespective of underlying risk-status.  This approach contributes to the over-treatment of up to half of all children with FN and has the potential to negatively impact patient and family quality of life and increase health care expenditures. The Predicting Infectious ComplicatioNs In Children with Cancer (PICCNIC) study evaluates the utility of a clinical decision rule for early oral antibiotic switch and discharge in patients who would traditionally remain in hospital for the duration of their antibiotic treatment. A sub-study in collaboration with Prof Pellegrini (WEHI) will determine potential biomarkers for inclusion into a risk prediction model. 


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